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  "Description": "A general framework using mixture Weibull distributions to\naccurately predict biomarker-guided trial duration accounting\nfor heterogeneous population. Extensive simulations are\nperformed to evaluate the impact of heterogeneous population\nand the dynamics of biomarker characteristics and disease on\nthe study duration. Several influential parameters including\nmedian survival time, enrollment rate, biomarker prevalence and\neffect size are identified. Efficiency gains of\nbiomarker-guided trials can be quantitatively compared to the\ntraditional all-comers design. For reference, see Zhang et al.\n(2024) <arXiv:2401.00540>.",
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